This is the part from GMG's post of the link that Sandi gave that had me ask the question......
Soaking in Acetone is going to be very dehydrating. That process is only temporary and moisture levels return to normal.
But that drying effect can start to cause problems when done frequently.
The issue isnt so much acetone as it is with solvents in general. Solvents (in this context) are designed to remove things like enamels and product, but when they do that, they also remove oil and moisture.
When that happens, the nail plate (and skin) can become subtly damaged until they become rehydrated again. When you strip oil and moisture from the plate, you take away all of the lubrication for the keratin polymer that makes up the plate. That makes the keratin brittle and the keratin polymer chains more likely to 'snap' away from one another under duress.
Frequent use of solvents can keep the keratin overly dry and in this fragile state for great lengths of time. The longer its left in this state, the more damage can occur.
Take hand washing as an example. We all wash our hands frequently throughout the day with no problems whatsoever. When people start to wash their hands excessively (like compulsive hand washers) they begin to have lots of skin problems because they are constantly stripping all the oil and moisture from their skin. The Keratin polymer in the skin becomes too brittle and dry and can no longer hold itself together.
I guess in summary... Any solvent is fine for the plate within certain limits. When you begin to exceed those limits, then you can start to have excessive problems.